Exercise Training-Induced Extracellular Matrix Protein Adaptation in Locomotor Muscles: A Systematic Review

Exercise training promotes muscle adaptation and remodelling by balancing the processes of anabolism catabolism; however, mechanisms which exercise delays accelerated wasting are not fully understood. Intramuscular extracellular matrix (ECM) proteins essential to tissue structure function, as they create a responsive environment for survival repair fibres. However, their role in is underappreciated underinvestigated. The PubMed, COCHRANE, Scopus CIHNAL databases were systematically searched from inception until February 2021. inclusion criteria on ECM after healthy adult population. Evidence 21 studies 402 participants demonstrates that induces remodelling, this accompanied adaptation. All types interventions promoted widespread increase collagens, glycoproteins proteoglycans transcriptomes younger older participants. controlling highlighted here concerned with myogenic angiogenic during remodelling. Further research identifying underlying link between ECMs will support discovery novel therapeutic targets development personalised medicine.